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EphA6
Receptor tyrosine kinase which binds promiscuously GPI- anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.7.10.1; Eph family; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group |
| Chromosomal Location of Human Ortholog: 16|16 C1.3 |
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Cellular Component:
cytoplasm; integral component of membrane; integral component of plasma membrane; membrane; neuron projection; nucleoplasm; receptor complex
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Molecular Function:
ATP binding; ephrin receptor activity; kinase activity; MAP kinase kinase kinase activity; mitogen-activated protein kinase kinase binding; nucleotide binding; protein kinase activity; protein tyrosine kinase activity; transferase activity; transmembrane receptor activity; transmembrane receptor protein tyrosine kinase activity; transmembrane-ephrin receptor activity
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Biological Process:
cell differentiation; multicellular organism development; negative regulation of apoptosis; negative regulation of signal transduction; phosphorylation; positive regulation of ERK1 and ERK2 cascade; positive regulation of kinase activity; positive regulation of MAPK cascade; protein amino acid phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway
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Reference #:
Q62413
(UniProtKB)
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Alt. Names/Synonyms: EHK-2; Ehk2; EPH homology kinase 2; Eph receptor A6; Epha6; Ephrin type-A receptor 6; Hek12; m-ehk2; OTTMUSP00000032093
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Gene Symbols: Epha6
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Molecular weight:
116,185 Da
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Basal Isoelectric point:
6.51
Predict pI for various phosphorylation states
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CST Pathways:
Tyrosine Kinases & Substrates
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