EphB6 Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation, T-cell receptor-induced IL-2 secretion and CD25 expression upon stimulation with ephrin-B2. Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. Expressed in brain. Expressed in non invasive breast carcinoma cell lines (at protein level). Strong expression in brain and pancreas, and weak expression in other tissues, such as heart, placenta, lung, liver, skeletal muscle and kidney. Expressed in breast non invasive tumors but not in metastatic lesions. Isoform 3 is expressed in cell lines of glioblastomas, anaplastic astrocytomas, gliosarcomas and astrocytomas. Isoform 3 is not detected in normal tissues. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Eph family; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group
Chromosomal Location of mouse Ortholog: 6|6 B2.1
Cellular Component:  cell surface; extracellular region; membrane; neuron projection; plasma membrane; receptor complex
Molecular Function:  ATP binding; ephrin receptor activity; nucleotide binding; protein kinase activity; transmembrane receptor protein tyrosine kinase activity; transmembrane-ephrin receptor activity
Biological Process:  activated T cell proliferation; axon guidance; central nervous system projection neuron axonogenesis; cytokine production; multicellular organism development; positive regulation of kinase activity; positive regulation of protein binding; positive regulation of T cell costimulation; protein phosphorylation; T cell mediated immunity; transmembrane receptor protein tyrosine kinase signaling pathway; type IV hypersensitivity
Reference #:  O08644 (UniProtKB)
Alt. Names/Synonyms: Cek; Cekl; chicken eph/elk receptor-like protein; Eph receptor B6; Ephb6; ephrin type A receptor; Ephrin type-B receptor 6; MEP; Tyrosine-protein kinase-defective receptor EPH-6
Gene Symbols: Ephb6
Molecular weight: 110,107 Da
Basal Isoelectric point: 6.37  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene