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CNOT8
Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT7. Catalytic component of the CCR4-NOT complex which is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity. Belongs to the CAF1 family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.1.13.4 |
| Chromosomal Location of human Ortholog: 5q33.2 |
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Cellular Component:
CCR4-NOT complex; CCR4-NOT core complex; cytosol; nucleus; P-body
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Molecular Function:
3'-5'-exoribonuclease activity; metal ion binding; poly(A)-specific ribonuclease activity; protein binding; RNA binding
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Biological Process:
DNA-templated transcription; exonucleolytic catabolism of deadenylated mRNA; miRNA-mediated gene silencing; nuclear-transcribed mRNA poly(A) tail shortening; positive regulation of cell population proliferation; positive regulation of mRNA catabolic process; RNA phosphodiester bond hydrolysis, exonucleolytic
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Reference #:
Q9UFF9
(UniProtKB)
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Alt. Names/Synonyms: CAF1; CAF1-like protein; Caf1b; CAF2; CALIF; CALIFp; CCR4-associated factor 8; CCR4-NOT transcription complex subunit 8; CCR4-NOT transcription complex, subunit 8; CNOT8; hCAF1; PGK promoter directed over production; POP2
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Gene Symbols: CNOT8
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Molecular weight:
33,540 Da
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Basal Isoelectric point:
4.69
Predict pI for various phosphorylation states
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