CNOT8 Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT7. Catalytic component of the CCR4-NOT complex which is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity. Belongs to the CAF1 family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC
Chromosomal Location of human Ortholog: 5q33.2
Cellular Component:  CCR4-NOT complex; CCR4-NOT core complex; cytosol; nucleus; P-body
Molecular Function:  3'-5'-exoribonuclease activity; metal ion binding; poly(A)-specific ribonuclease activity; protein binding; RNA binding
Biological Process:  DNA-templated transcription; exonucleolytic catabolism of deadenylated mRNA; miRNA-mediated gene silencing; nuclear-transcribed mRNA poly(A) tail shortening; positive regulation of cell population proliferation; positive regulation of mRNA catabolic process; RNA phosphodiester bond hydrolysis, exonucleolytic
Reference #:  Q9UFF9 (UniProtKB)
Alt. Names/Synonyms: CAF1; CAF1-like protein; Caf1b; CAF2; CALIF; CALIFp; CCR4-associated factor 8; CCR4-NOT transcription complex subunit 8; CCR4-NOT transcription complex, subunit 8; CNOT8; hCAF1; PGK promoter directed over production; POP2
Gene Symbols: CNOT8
Molecular weight: 33,540 Da
Basal Isoelectric point: 4.69  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene