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EphB6
Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation, T-cell receptor-induced IL-2 secretion and CD25 expression upon stimulation with ephrin-B2. Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. Expressed in brain. Expressed in non invasive breast carcinoma cell lines (at protein level). Strong expression in brain and pancreas, and weak expression in other tissues, such as heart, placenta, lung, liver, skeletal muscle and kidney. Expressed in breast non invasive tumors but not in metastatic lesions. Isoform 3 is expressed in cell lines of glioblastomas, anaplastic astrocytomas, gliosarcomas and astrocytomas. Isoform 3 is not detected in normal tissues. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.7.10.1; Eph family; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group |
| Chromosomal Location of human Ortholog: 7q34 |
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Cellular Component:
cytosol; dendrite; extracellular region; plasma membrane
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Molecular Function:
ATP binding; ephrin receptor activity; protein binding; signaling receptor activity; transmembrane-ephrin receptor activity
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Biological Process:
axon guidance; ephrin receptor signaling pathway; protein phosphorylation
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Reference #:
O15197
(UniProtKB)
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Alt. Names/Synonyms: EPH receptor B6; EPHB6; Ephrin type-B receptor 6; HEP; human kinase-defective Eph-family receptor protein; MGC129910; MGC129911; Tyrosine-protein kinase-defective receptor EPH-6
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Gene Symbols: EPHB6
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Molecular weight:
110,700 Da
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Basal Isoelectric point:
6.19
Predict pI for various phosphorylation states
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CST Pathways:
Tyrosine Kinases & Substrates
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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