EphB4 Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 it is involved in the regulation of cell adhesion and migration, and plays a central role in heart morphogenesis, angiogenesis and blood vessel remodeling and permeability. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. Abundantly expressed in placenta but also detected in kidney, liver, lung, pancreas, skeletal muscle and heart. Expressed in primitive and myeloid, but not lymphoid, hematopoietic cells. Also observed in cell lines derived from liver, breast, colon, lung, melanocyte and cervix. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Eph family; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group
Chromosomal Location of Human Ortholog: 5|5 G2
Cellular Component:  integral component of membrane; integral component of plasma membrane; membrane; neuron projection; plasma membrane; receptor complex
Molecular Function:  ATP binding; ephrin receptor activity; kinase activity; nucleotide binding; protein binding; protein kinase activity; protein tyrosine kinase activity; transferase activity; transmembrane receptor protein tyrosine kinase activity; transmembrane-ephrin receptor activity
Biological Process:  angiogenesis; axon guidance; cell adhesion; cell migration involved in sprouting angiogenesis; ephrin receptor signaling pathway; heart morphogenesis; multicellular organism development; phosphorylation; positive regulation of aorta morphogenesis; positive regulation of T cell costimulation; protein autophosphorylation; protein phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; venous blood vessel morphogenesis
Reference #:  P54761 (UniProtKB)
Alt. Names/Synonyms: AI042935; b2b2412C; b2b2412Clo; Developmental kinase 2; Eph receptor B4; Ephb4; Ephrin type-B receptor 4; Hepatoma transmembrane kinase; Htk; mDK-2; Mdk2; Myk1; OTTMUSP00000024612; Tyro; Tyro11; Tyrosine kinase MYK-1
Gene Symbols: Ephb4
Molecular weight: 108,848 Da
Basal Isoelectric point: 6.53  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein