FBXO25 Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT). A chromosomal aberration involving FBXO25 is a cause of X-linked mental retardation (XLMR). Translocation t(X;8)(p11.22;p23.3) with SHROOM4. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 8p23.3
Cellular Component:  nucleus; SCF ubiquitin ligase complex; ubiquitin ligase complex
Molecular Function:  actin binding; ubiquitin-protein transferase activity
Biological Process:  protein ubiquitination
Reference #:  Q8TCJ0 (UniProtKB)
Alt. Names/Synonyms: F-box only protein 25; F-box protein 25; F-box protein Fbx25; FBX25; FBXO25; MGC20256; MGC51975
Gene Symbols: FBXO25
Molecular weight: 43,313 Da
Basal Isoelectric point: 8.35  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein