EphB4 Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 it is involved in the regulation of cell adhesion and migration, and plays a central role in heart morphogenesis, angiogenesis and blood vessel remodeling and permeability. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. Abundantly expressed in placenta but also detected in kidney, liver, lung, pancreas, skeletal muscle and heart. Expressed in primitive and myeloid, but not lymphoid, hematopoietic cells. Also observed in cell lines derived from liver, breast, colon, lung, melanocyte and cervix. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.10.1; Eph family; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group
Chromosomal Location of Human Ortholog: 7q22.1
Cellular Component:  cytosol; extracellular region; integral component of plasma membrane; plasma membrane
Molecular Function:  ATP binding; ephrin receptor activity; protein binding; transmembrane receptor protein tyrosine kinase activity
Biological Process:  angiogenesis; cell adhesion; cell migration involved in sprouting angiogenesis; ephrin receptor signaling pathway; heart morphogenesis; peptidyl-tyrosine phosphorylation; protein autophosphorylation
Disease: Capillary Malformation-arteriovenous Malformation 2; Hydrops Fetalis, Nonimmune, And/or Atrial Septal Defect, Susceptibility To
Reference #:  P54760 (UniProtKB)
Alt. Names/Synonyms: EPH receptor B4; EPHB4; ephrin receptor EphB4; Ephrin type-B receptor 4; hepatoma transmembrane kinase; HTK; MYK1; soluble EPHB4 variant 1; soluble EPHB4 variant 2; soluble EPHB4 variant 3; TYRO11; Tyrosine-protein kinase receptor HTK; Tyrosine-protein kinase TYRO11
Gene Symbols: EPHB4
Molecular weight: 108,270 Da
Basal Isoelectric point: 6.48  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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EphB4

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene