|
SCUBE1
Could function as an adhesive molecule and its matrix bound and soluble fragments may play a critical role in vascular biology. Detected in endothelial cells. Highly expressed in platelets. Stored in platelet alpha granules, and transferred to the cell surface upon activation and aggregation. A smaller form, probably produced by limited proteolysis, after being released from the storage granules, is associated with thrombus and localized with the subendothelial matrices in atherosclerotic plaques. Note: This description may include information from UniProtKB.
|
| Chromosomal Location of human Ortholog: 22q13.2 |
|
Cellular Component:
cell surface; external side of plasma membrane; extracellular space; plasma membrane
|
|
Molecular Function:
calcium ion binding; identical protein binding; protein binding
|
|
Biological Process:
adult heart development; blood coagulation; endothelial cell differentiation; inflammatory response; positive regulation of smoothened signaling pathway; post-embryonic development; signal transduction
|
|
Reference #:
Q8IWY4
(UniProtKB)
|
|
Alt. Names/Synonyms: SCUB1; SCUBE1; Signal peptide, CUB and EGF-like domain-containing protein 1; signal peptide, CUB domain and EGF like domain containing 1; signal peptide, CUB domain, EGF-like 1; signal peptide-CUB domain-EGF-related 1
|
|
Gene Symbols: SCUBE1
|
|
Molecular weight:
107,910 Da
|
|
Basal Isoelectric point:
6.42
Predict pI for various phosphorylation states
|
