TMEM108
Transmembrane protein required for proper cognitive functions. Involved in the development of dentate gyrus (DG) neuron circuitry, is neccessary for AMPA receptors surface expression and proper excitatory postsynaptic currents of DG granule neurons. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Through the interaction with DST, mediates the docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport. In hippocampal neurons, required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 and recruits the WAVE1 complex to facilitate actin-dependent BDNF:NTRK2 early endocytic trafficking and mediate signaling from early endosomes. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Cancer Testis Antigen (CTA); Membrane protein, integral |
Chromosomal Location of mouse Ortholog: 9|9 F1 |
Cellular Component:
axon; cell projection; early endosome; endosome; endosome membrane; membrane; postsynaptic density; somatodendritic compartment; synapse
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Molecular Function:
protein binding
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Biological Process:
cellular response to brain-derived neurotrophic factor stimulus; dendrite extension; dentate gyrus development; modulation of excitatory postsynaptic potential; neuron projection development; positive regulation of neurotrophin TRK receptor signaling pathway; postsynaptic density organization; receptor-mediated endocytosis; retrograde axonal transport
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Reference #:
Q8BHE4
(UniProtKB)
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Alt. Names/Synonyms: AI462967; B130017P16Rik; CT 124; KIAA1690; R74726; Retrolinkin; TM108; Tmem108; Transmembrane protein 108
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Gene Symbols: Tmem108
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Molecular weight:
59,642 Da
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Basal Isoelectric point:
8.7
Predict pI for various phosphorylation states
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