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STEAP2
Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor. Belongs to the STEAP family. Expressed at high levels in prostate and at significantly lower levels in heart, brain, kidney, pancreas, and ovary. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 1.16.1.-; Membrane protein, integral; Membrane protein, multi-pass; Oxidoreductase; Vesicle |
| Chromosomal Location of human Ortholog: 7q21.13 |
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Cellular Component:
cytosol; early endosome; endosome; endosome membrane; Golgi membrane; plasma membrane; trans-Golgi network transport vesicle
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Molecular Function:
cupric reductase activity; ferric-chelate reductase (NADPH) activity; metal ion binding
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Biological Process:
copper ion import; copper ion import across plasma membrane; endocytosis; Golgi to plasma membrane transport; iron ion import across plasma membrane; regulated exocytosis; response to hormone
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Reference #:
Q8NFT2
(UniProtKB)
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Alt. Names/Synonyms: IPCA1; Metalloreductase STEAP2; PCANAP1; prostate cancer associated protein 1; Prostate cancer-associated protein 1; Protein up-regulated in metastatic prostate cancer; Protein upregulated in metastatic prostate cancer; PUMPCn; six transmembrane epithelial antigen of prostate 2; six transmembrane epithelial antigen of the prostate 2; Six-transmembrane epithelial antigen of prostate 2; SixTransMembrane protein of prostate 1; STAMP1; STEA2; STEAP family member 2, metalloreductase; STEAP2; STEAP2 metalloreductase; STMP
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Gene Symbols: STEAP2
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Molecular weight:
56,056 Da
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Basal Isoelectric point:
9.28
Predict pI for various phosphorylation states
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