STEAP2 Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor. Belongs to the STEAP family. Expressed at high levels in prostate and at significantly lower levels in heart, brain, kidney, pancreas, and ovary. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 1.16.1.-; Membrane protein, integral; Membrane protein, multi-pass; Oxidoreductase; Vesicle
Chromosomal Location of human Ortholog: 7q21.13
Cellular Component:  cytosol; early endosome; endosome; endosome membrane; Golgi membrane; plasma membrane; trans-Golgi network transport vesicle
Molecular Function:  cupric reductase activity; ferric-chelate reductase (NADPH) activity; metal ion binding
Biological Process:  copper ion import; copper ion import across plasma membrane; endocytosis; Golgi to plasma membrane transport; iron ion import across plasma membrane; regulated exocytosis; response to hormone
Reference #:  Q8NFT2 (UniProtKB)
Alt. Names/Synonyms: IPCA1; Metalloreductase STEAP2; PCANAP1; prostate cancer associated protein 1; Prostate cancer-associated protein 1; Protein up-regulated in metastatic prostate cancer; Protein upregulated in metastatic prostate cancer; PUMPCn; six transmembrane epithelial antigen of prostate 2; six transmembrane epithelial antigen of the prostate 2; Six-transmembrane epithelial antigen of prostate 2; SixTransMembrane protein of prostate 1; STAMP1; STEA2; STEAP family member 2, metalloreductase; STEAP2; STEAP2 metalloreductase; STMP
Gene Symbols: STEAP2
Molecular weight: 56,056 Da
Basal Isoelectric point: 9.28  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene