SULT1B1 Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates dopamine, small phenols such as 1-naphthol and p-nitrophenol and thyroid hormones, including 3,3'-diiodothyronine, triidothyronine, reverse triiodothyronine and thyroxine. Belongs to the sulfotransferase 1 family. Note: This description may include information from UniProtKB.
Protein type: EC 2.8.2.-; Transferase
Chromosomal Location of Human Ortholog: 4q13.3
Cellular Component:  cytosol
Molecular Function:  aryl sulfotransferase activity; protein binding; sulfotransferase activity
Biological Process:  3'-phosphoadenosine 5'-phosphosulfate metabolic process; biogenic amine metabolic process; epithelial cell differentiation; ethanol catabolic process; flavonoid metabolic process; phenol-containing compound metabolic process; steroid metabolic process; sulfation; thyroid hormone metabolic process; xenobiotic metabolic process
Reference #:  O43704 (UniProtKB)
Alt. Names/Synonyms: MGC13356; ST1B1; ST1B2; Sulfotransferase 1B1; Sulfotransferase 1B2; Sulfotransferase family cytosolic 1B member 1; sulfotransferase family, cytosolic, 1B, member 1; SULT1B1; SULT1B2; Thyroid hormone sulfotransferase
Gene Symbols: SULT1B1
Molecular weight: 34,899 Da
Basal Isoelectric point: 6.57  Predict pI for various phosphorylation states
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SULT1B1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB