PIGB Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third alpha-1,2-mannose to Man2-GlcN-acyl-PI during GPI precursor assembly. Belongs to the glycosyltransferase 22 family. PIGB subfamily. Note: This description may include information from UniProtKB.
Protein type: EC 2.4.1.-; Endoplasmic reticulum; Glycan Metabolism - glycosylphosphatidylinositol (GPI)-anchor biosynthesis; Membrane protein, integral; Membrane protein, multi-pass; Transferase
Chromosomal Location of Human Ortholog: 15q21.3
Cellular Component:  endoplasmic reticulum membrane; integral component of membrane
Molecular Function:  glycolipid mannosyltransferase activity; mannosyltransferase activity
Biological Process:  GPI anchor biosynthetic process; mannosylation; preassembly of GPI anchor in ER membrane
Disease: Epileptic Encephalopathy, Early Infantile, 80
Reference #:  Q92521 (UniProtKB)
Alt. Names/Synonyms: dol-P-Man dependent GPI mannosyltransferase; EIEE80; GPI mannosyltransferase 3; GPI mannosyltransferase III; GPI-MT-III; MGC21236; phosphatidylinositol glycan anchor biosynthesis class B; phosphatidylinositol glycan anchor biosynthesis, class B; phosphatidylinositol glycan, class B; Phosphatidylinositol-glycan biosynthesis class B protein; PIG-B; PIGB
Gene Symbols: PIGB
Molecular weight: 65,056 Da
Basal Isoelectric point: 9.39  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB