EphA5 Receptor tyrosine kinase which binds promiscuously GPI- anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 most probably constitutes the cognate/functional ligand for EPHA5. Functions as an axon guidance molecule during development and may be involved in the development of the retinotectal, entorhino- hippocampal and hippocamposeptal pathways. Together with EFNA5 plays also a role in synaptic plasticity in adult brain through regulation of synaptogenesis. Beside its function in the nervous system, the interaction of EPHA5 with EFNA5 mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion. Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC; Eph family; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group
Chromosomal Location of Human Ortholog: 4q13.1-q13.2
Cellular Component:  axon; cell soma; cytoplasm; dendrite; external side of plasma membrane; integral component of plasma membrane; neuron projection; perinuclear region of cytoplasm; plasma membrane; receptor complex; rough endoplasmic reticulum
Molecular Function:  ATP binding; ephrin receptor activity; GPI-linked ephrin receptor activity; MAP kinase kinase kinase activity; mitogen-activated protein kinase kinase binding; protein tyrosine kinase activity; transmembrane receptor activity; transmembrane receptor protein tyrosine kinase activity; transmembrane-ephrin receptor activity
Biological Process:  axon guidance; cAMP-mediated signaling; cell differentiation; ephrin receptor signaling pathway; hippocampus development; multicellular organism development; negative regulation of apoptosis; negative regulation of signal transduction; neuron development; peptidyl-tyrosine phosphorylation; positive regulation of CREB transcription factor activity; positive regulation of ERK1 and ERK2 cascade; positive regulation of kinase activity; positive regulation of MAPK cascade; regulation of actin cytoskeleton organization; regulation of GTPase activity
Reference #:  P54756 (UniProtKB)
Alt. Names/Synonyms: CEK7; EHK-1; EHK1; EK7; EPH homology kinase 1; Eph homology kinase-1; EPH receptor A5; EPH-like kinase 7; EPHA5; ephrin receptor EphA5; Ephrin type-A receptor 5; HEK7; receptor protein-tyrosine kinase HEK7; TYRO4; tyrosine-protein kinase receptor EHK-1
Gene Symbols: EPHA5
Molecular weight: 114,803 Da
Basal Isoelectric point: 6.53  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  CCLE  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein