COPS4 Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. Also involved in the deneddylation of non-cullin subunits such as STON2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1, IRF8/ICSBP and SNAPIN, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Belongs to the CSN4 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Unknown function
Chromosomal Location of human Ortholog: 4q21.22
Cellular Component:  cell junction; COP9 signalosome; cytosol; nuclear speck; nucleoplasm; synaptic vesicle
Molecular Function:  NEDD8-specific protease activity; protein binding
Biological Process:  nucleotide-excision repair, DNA damage recognition; post-translational protein modification; protein deneddylation; transcription-coupled nucleotide-excision repair
Reference #:  Q9BT78 (UniProtKB)
Alt. Names/Synonyms: COP9 constitutive photomorphogenic homolog subunit 4; COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis); COP9 constitutive photomorphogenic-like protein subunit 4; COP9 signalosome complex subunit 4; COP9 signalosome subunit 4; COPS4; CSN4; JAB1-containing signalosome subunit 4; MGC10899; MGC15160; SGN4; Signalosome subunit 4; testis tissue sperm-binding protein Li 42a
Gene Symbols: COPS4
Molecular weight: 46,269 Da
Basal Isoelectric point: 5.57  Predict pI for various phosphorylation states
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COPS4

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene