ZBTB17 Transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. Plays a critical role in early lymphocyte development, where it is essential to prevent apoptosis in lymphoid precursors, allowing them to survive in response to IL7 and undergo proper lineage commitment. Has been shown to bind to the promoters of adenovirus major late protein and cyclin D1 and activate transcription. Required for early embryonic development during gastrulation. Represses RB1 transcription; this repression can be blocked by interaction with ZBTB49 isoform 3/ZNF509S1. Belongs to the krueppel C2H2-type zinc-finger protein family. Expressed in germinal center B-cells. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein; DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 4|4 D3
Cellular Component:  nucleus; protein-containing complex; protein-DNA complex
Molecular Function:  core promoter binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; metal ion binding; nucleic acid binding; protein binding; RNA polymerase II proximal promoter sequence-specific DNA binding; transcription coactivator binding; transcription factor binding
Biological Process:  ectoderm development; gastrulation with mouth forming second; multicellular organism development; negative regulation of cell proliferation; positive regulation of cell cycle arrest; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated
Reference #:  Q60821 (UniProtKB)
Alt. Names/Synonyms: AA589413; LP-1; Miz1; mZ13; OTTMUSP00000010988; Polyomavirus late initiator promoter-binding protein; ZBT17; Zbtb17; Zfp-100; Zfp100; zinc finger and BTB domain containing 17; Zinc finger and BTB domain-containing protein 17; Zinc finger protein 100; Zinc finger protein 151; Zinc finger protein Z13; Znf151
Gene Symbols: Zbtb17
Molecular weight: 86,758 Da
Basal Isoelectric point: 6.08  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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ZBTB17

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene