EphA3 Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in cardiac cells migration and differentiation and regulates the formation of the atrioventricular canal and septum during development probably through activation by EFNA1. Involved in the retinotectal mapping of neurons. May also control the segregation but not the guidance of motor and sensory axons during neuromuscular circuit development. Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. Widely expressed. Highest level in placenta. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Eph family; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group
Chromosomal Location of Human Ortholog: 16|16 C1.3
Cellular Component:  early endosome; extracellular region; GABA-ergic synapse; integral component of membrane; integral component of plasma membrane; membrane; neuron projection; plasma membrane; presynapse; receptor complex
Molecular Function:  ATP binding; ephrin receptor activity; GPI-linked ephrin receptor activity; kinase activity; nucleotide binding; protein binding; protein kinase activity; protein tyrosine kinase activity; transferase activity; transmembrane receptor protein tyrosine kinase activity; transmembrane-ephrin receptor activity
Biological Process:  axon guidance; cell migration; cellular response to follicle-stimulating hormone stimulus; cellular response to retinoic acid; endocardial cushion development; ephrin receptor signaling pathway; fasciculation of motor neuron axon; fasciculation of sensory neuron axon; negative regulation of endocytosis; negative regulation of neuron projection development; peptidyl-tyrosine phosphorylation; phosphorylation; positive regulation of neuron projection development; positive regulation of protein localization to plasma membrane; protein phosphorylation; regulation of actin cytoskeleton organization; regulation of cell migration; regulation of epithelial to mesenchymal transition; regulation of focal adhesion assembly; regulation of GTPase activity; regulation of microtubule cytoskeleton organization; synaptic membrane adhesion; transmembrane receptor protein tyrosine kinase signaling pathway
Reference #:  P29319 (UniProtKB)
Alt. Names/Synonyms: AW492086; Cek4; EK4; End; End3; Eph receptor A3; EPH-like kinase 4; Epha3; Ephrin type-A receptor 3; Etk1; Hek; Hek4; Mek4; Tyr; Tyro4; Tyrosine-protein kinase receptor ETK1; Tyrosine-protein kinase TYRO4
Gene Symbols: Epha3
Molecular weight: 109,955 Da
Basal Isoelectric point: 6.87  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene