TNR Neural extracellular matrix (ECM) protein involved in interactions with different cells and matrix components. These interactions can influence cellular behavior by either evoking a stable adhesion and differentiation, or repulsion and inhibition of neurite growth. Binding to cell surface gangliosides inhibits RGD-dependent integrin-mediated cell adhesion and results in an inhibition of PTK2/FAK1 (FAK) phosphorylation and cell detachment. Binding to membrane surface sulfatides results in a oligodendrocyte adhesion and differentiation. Interaction with CNTN1 induces a repulsion of neurons and an inhibition of neurite outgrowth. Interacts with SCN2B may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier. TNR-linked chondroitin sulfate glycosaminoglycans are involved in the interaction with FN1 and mediate inhibition of cell adhesion and neurite outgrowth. The highly regulated addition of sulfated carbohydrate structure may modulate the adhesive properties of TNR over the course of development and during synapse maintenance. Belongs to the tenascin family. Brain specific. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide
Chromosomal Location of human Ortholog: 1q25.1
Cellular Component:  cell surface; collagen-containing extracellular matrix; extracellular region; extracellular space; glutamatergic synapse; membrane raft; perineuronal net; Schaffer collateral - CA1 synapse; tenascin complex
Molecular Function:  signaling receptor binding
Biological Process:  associative learning; axon extension involved in regeneration; axon guidance; cell adhesion; extracellular matrix organization; locomotory exploration behavior; long-term synaptic potentiation; negative regulation of axon extension involved in regeneration; negative regulation of cell-cell adhesion; negative regulation of neuron projection development; negative regulation of synaptic transmission; neuromuscular process controlling balance; neuron cell-cell adhesion; positive regulation of synaptic transmission, glutamatergic; positive regulation of transmission of nerve impulse; regulation of cell adhesion; regulation of cell differentiation; regulation of cell migration; synapse organization; synaptic transmission, glutamatergic; telencephalon cell migration
Disease: Neurodevelopmental Disorder, Nonprogressive, With Spasticity And Transient Opisthotonus
Reference #:  Q92752 (UniProtKB)
Alt. Names/Synonyms: Janusin; MGC149328; Restrictin; tenascin R; tenascin R (restrictin, janusin); Tenascin-R; TENR; TN-R; TNR
Gene Symbols: TNR
Molecular weight: 149,562 Da
Basal Isoelectric point: 4.71  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene