|
TG
Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3). Belongs to the type-B carboxylesterase/lipase family. Thyroid gland specific. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: Secreted; Secreted, signal peptide |
| Chromosomal Location of mouse Ortholog: 15 D2|15 29.3 cM |
|
Cellular Component:
extracellular region; extracellular space; perinuclear region of cytoplasm; protein-containing complex
|
|
Molecular Function:
anion binding; hormone activity; identical protein binding; protein-containing complex binding; protein-folding chaperone binding; signaling receptor binding
|
|
Biological Process:
hormone biosynthetic process; iodide transport; regulation of myelination; response to pH; thyroid hormone generation; thyroid hormone metabolic process; transcytosis
|
|
Reference #:
O08710
(UniProtKB)
|
|
Alt. Names/Synonyms: cog; congenital goiter; MGC117699; Tg; Tgn; THYG; Thyroglobulin
|
|
Gene Symbols: Tg
|
|
Molecular weight:
304,473 Da
|
|
Basal Isoelectric point:
5.32
Predict pI for various phosphorylation states
|
