TG Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3). Belongs to the type-B carboxylesterase/lipase family. Thyroid gland specific. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of human Ortholog: 8q24.22
Cellular Component:  extracellular region
Molecular Function:  hormone activity
Biological Process:  hormone biosynthetic process; iodide transport; regulation of myelination; regulation of signaling receptor activity; signal transduction; thyroid gland development; thyroid hormone metabolic process
Disease: Autoimmune Thyroid Disease, Susceptibility To, 3; Thyroid Dyshormonogenesis 3
Reference #:  P01266 (UniProtKB)
Alt. Names/Synonyms: AITD3; TG; TGN; THYG; Thyroglobulin
Gene Symbols: TG
Molecular weight: 304,790 Da
Basal Isoelectric point: 5.4  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  CCLE  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene