EphA3 Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in cardiac cells migration and differentiation and regulates the formation of the atrioventricular canal and septum during development probably through activation by EFNA1. Involved in the retinotectal mapping of neurons. May also control the segregation but not the guidance of motor and sensory axons during neuromuscular circuit development. Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. Widely expressed. Highest level in placenta. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Protein type: EC 2.7.10.1; Eph family; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group

Chromosomal Location of human Ortholog: 3p11.1

Cellular Component: actin cytoskeleton; cytosol; dendrite; early endosome; extracellular region; nuclear membrane; nucleoplasm; plasma membrane

Molecular Function: ATP binding; ephrin receptor activity; GPI-linked ephrin receptor activity; protein binding; transmembrane-ephrin receptor activity

Biological Process: axon guidance; cell adhesion; cell migration; cellular response to retinoic acid; ephrin receptor signaling pathway; fasciculation of motor neuron axon; fasciculation of sensory neuron axon; negative regulation of endocytosis; peptidyl-tyrosine phosphorylation; positive regulation of neuron projection development; positive regulation of protein localization to plasma membrane; protein phosphorylation; regulation of actin cytoskeleton organization; regulation of epithelial to mesenchymal transition; regulation of focal adhesion assembly; regulation of GTPase activity; regulation of microtubule cytoskeleton organization

Reference #: P29320 (UniProtKB)

Alt. Names/Synonyms: EK4; EPH receptor A3; EPH-like kinase 4; eph-like tyrosine kinase 1; EPHA3; ephrin receptor EphA3; Ephrin type-A receptor 3; ETK; ETK1; HEK; hEK4; Human embryo kinase; human embryo kinase 1; testicular tissue protein Li 64; TYRO4; TYRO4 protein tyrosine kinase; Tyrosine-protein kinase receptor ETK1; Tyrosine-protein kinase TYRO4

Gene Symbols: EPHA3

Molecular weight: 110,131 Da

Basal Isoelectric point: 6.33 Predict pI for various phosphorylation states

CST Pathways: Tyrosine Kinases & Substrates

Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology^®

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EphA3

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