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EphA3
a receptor tyrosine kinase of the Eph family. Receptor for members of the ephrin-A family: binds to ephrin-A2, -A3, -A4 and -A5The Eph receptor tyrosine kinase family, the largest in the tyrosine kinase group, has fourteen members. They bind membrane-anchored ligands, ephrins, at sites of cell-cell contact, regulating the repulsion and adhesion of cells that underlie the establishment, maintenance, and remodeling of patterns of cellular organization. Eph signals are particularly important in regulating cell adhesion and cell migration during development, axon guidance, homeostasis and disease. EphA receptors bind to GPI-anchored ephrin-A ligands, while EphB receptors bind to ephrin-B proteins that have a transmembrane and cytoplasmic domain. Interactions between EphB receptor kinases and ephrin-B proteins transduce signals bidirectionally, signaling to both interacting cell types. Eph receptors and ephrins also regulate the adhesion of endothelial cells and are required for the remodeling of blood vessels. Two point mutations seen in a survey of colorectal tumors. Soluble receptors reduce tumor growth and angiogenesis in mouse models. Two alternatively spliced isoforms of EphA3 have been described. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.7.10.1; Eph family; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group |
| Chromosomal Location of Human Ortholog: 3p11.1 |
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Cellular Component:
cytoplasm; early endosome; extracellular region; integral component of plasma membrane; neuron projection; plasma membrane; receptor complex
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Molecular Function:
ATP binding; GPI-linked ephrin receptor activity; MAP kinase kinase kinase activity; mitogen-activated protein kinase kinase binding; protein binding; protein tyrosine kinase activity; transmembrane receptor activity; transmembrane receptor protein tyrosine kinase activity; transmembrane-ephrin receptor activity
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Biological Process:
cell adhesion; cell differentiation; cell migration; cellular response to retinoic acid; ephrin receptor signaling pathway; multicellular organism development; negative regulation of apoptosis; negative regulation of endocytosis; negative regulation of signal transduction; peptidyl-tyrosine phosphorylation; positive regulation of ERK1 and ERK2 cascade; positive regulation of kinase activity; positive regulation of MAPK cascade; positive regulation of neuron projection development; regulation of actin cytoskeleton organization; regulation of epithelial to mesenchymal transition; regulation of focal adhesion formation; regulation of GTPase activity
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Reference #:
P29320
(UniProtKB)
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Alt. Names/Synonyms: EK4; EPH receptor A3; EPH-like kinase 4; eph-like tyrosine kinase 1; EPHA3; ephrin receptor EphA3; Ephrin type-A receptor 3; ETK; ETK1; HEK; hEK4; human embryo kinase 1; TYRO4; TYRO4 protein tyrosine kinase; Tyrosine-protein kinase receptor ETK1; Tyrosine-protein kinase TYRO4
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Gene Symbols: EPHA3
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Molecular weight:
110,131 Da
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Basal Isoelectric point:
6.33
Predict pI for various phosphorylation states
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CST Pathways:
Tyrosine Kinases & Substrates
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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