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CTHRC1
May act as a negative regulator of collagen matrix deposition. Isoform 1 is expressed in calcified atherosclerotic plaque and chondrocyte-like cells. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Secreted; Secreted, signal peptide |
| Chromosomal Location of human Ortholog: 8q22.3 |
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Cellular Component:
collagen trimer; extracellular space; sarcoplasm
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Molecular Function:
extracellular matrix structural constituent; frizzled binding; Wnt-protein binding
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Biological Process:
cochlea morphogenesis; establishment of planar polarity involved in neural tube closure; inner ear receptor cell stereocilium organization; negative regulation of canonical Wnt signaling pathway; ossification involved in bone remodeling; osteoblast differentiation; osteoblast proliferation; positive regulation of osteoblast differentiation; positive regulation of osteoblast proliferation; positive regulation of protein binding; Wnt signaling pathway, planar cell polarity pathway
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Disease: Barrett Esophagus
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Reference #:
Q96CG8
(UniProtKB)
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Alt. Names/Synonyms: collagen triple helix repeat containing 1; Collagen triple helix repeat-containing protein 1; CTHR1; CTHRC1; Q96CG8
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Gene Symbols: CTHRC1
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Molecular weight:
26,224 Da
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Basal Isoelectric point:
8.31
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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