CXXC5 May indirectly participate in activation of the NF-kappa-B and MAPK pathways. Acts as a mediator of BMP4-mediated modulation of canonical Wnt signaling activity in neural stem cells. Required for DNA damage-induced ATM phosphorylation, p53 activation and cell cycle arrest. Involved in myelopoiesis. Transcription factor. Binds to the oxygen responsive element of COX4I2 and represses its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen). May repress COX4I2 transactivation induced by CHCHD2 and RBPJ. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Chromosomal Location of Human Ortholog: 5q31.2
Cellular Component:  cytosol; nucleoplasm
Molecular Function:  protein binding; sequence-specific DNA binding; transcription factor binding; zinc ion binding
Biological Process:  negative regulation of transcription by RNA polymerase II
Reference #:  Q7LFL8 (UniProtKB)
Alt. Names/Synonyms: CF5; CXXC finger 5; CXXC finger 5 protein; CXXC finger protein 5; CXXC-type zinc finger protein 5; CXXC5; HSPC195; Putative MAPK-activating protein PM08; Putative NF-kappa-B-activating protein 102; Q7LFL8; retinoid-inducible nuclear factor; RINF; WID; WT1-induced Inhibitor of Dishevelled
Gene Symbols: CXXC5
Molecular weight: 32,977 Da
Basal Isoelectric point: 9.27  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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CXXC5

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein