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MIS12
Part of the MIS12 complex which is required for normal chromosome alignment and segregation and for kinetochore formation during mitosis. Essential for proper kinetochore microtubule attachments. Belongs to the mis12 family. Note: This description may include information from UniProtKB.
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| Chromosomal Location of human Ortholog: 17p13.2 |
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Cellular Component:
cytosol; kinetochore; MIS12/MIND type complex; nucleus
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Molecular Function:
protein binding
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Biological Process:
attachment of mitotic spindle microtubules to kinetochore; cell division; chromosome segregation; kinetochore assembly; mitotic sister chromatid segregation
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Reference #:
Q9H081
(UniProtKB)
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Alt. Names/Synonyms: 2510025F08Rik; hMis12; homolog of yeast Mis12; KNTC2AP; MGC2488; MIS12; MIS12 homolog; MIS12 kinetochore complex component; MIS12, MIND kinetochore complex component, homolog; MIS12, MIND kinetochore complex component, homolog (S. pombe); MTW1; OTTHUMP00000128206; Protein MIS12 homolog; Q9H081
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Gene Symbols: MIS12
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Molecular weight:
24,140 Da
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Basal Isoelectric point:
5.5
Predict pI for various phosphorylation states
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