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FBXO27
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Able to recognize and bind denatured glycoproteins, which are modified with complex-type oligosaccharides. Predominantly expressed in brain, heart and kidney. Expressed at lower levels in liver and lung. Note: This description may include information from UniProtKB.
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| Protein type: Ubiquitin ligase |
| Chromosomal Location of human Ortholog: 19q13.2 |
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Cellular Component:
cytoplasm; cytosol; SCF ubiquitin ligase complex
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Molecular Function:
protein binding; ubiquitin protein ligase activity
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Biological Process:
glycoprotein catabolic process; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; ubiquitin-dependent ERAD pathway
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Reference #:
Q8NI29
(UniProtKB)
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Alt. Names/Synonyms: epididymis secretory sperm binding protein; F-box only protein 27; F-box protein 27; F-box protein FBG5; F-box/G-domain protein 5; FBG5; Fbx27; FBXO27; Q8NI29
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Gene Symbols: FBXO27
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Molecular weight:
31,623 Da
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Basal Isoelectric point:
8.92
Predict pI for various phosphorylation states
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