FBXO27 Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Able to recognize and bind denatured glycoproteins, which are modified with complex-type oligosaccharides. Predominantly expressed in brain, heart and kidney. Expressed at lower levels in liver and lung. Note: This description may include information from UniProtKB.
Protein type: Ubiquitin ligase
Chromosomal Location of human Ortholog: 19q13.2
Cellular Component:  cytoplasm; cytosol; SCF ubiquitin ligase complex
Molecular Function:  protein binding; ubiquitin protein ligase activity
Biological Process:  glycoprotein catabolic process; protein ubiquitination; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; ubiquitin-dependent ERAD pathway
Reference #:  Q8NI29 (UniProtKB)
Alt. Names/Synonyms: epididymis secretory sperm binding protein; F-box only protein 27; F-box protein 27; F-box protein FBG5; F-box/G-domain protein 5; FBG5; Fbx27; FBXO27; Q8NI29
Gene Symbols: FBXO27
Molecular weight: 31,623 Da
Basal Isoelectric point: 8.92  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein