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SPTSSA
Stimulates the activity of serine palmitoyltransferase (SPT). The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. Plays a role in MBOAT7 location to mitochondria-associated membranes (MAMs), may me involved in fatty acid remodeling phosphatidylinositol (PI). Belongs to the SPTSS family. SPTSSA subfamily. Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, integral; Membrane protein, multi-pass |
| Chromosomal Location of human Ortholog: 14q13.1 |
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Cellular Component:
endoplasmic reticulum; endoplasmic reticulum membrane; serine C-palmitoyltransferase complex
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Molecular Function:
protein binding; serine C-palmitoyltransferase activity
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Biological Process:
ceramide biosynthetic process; protein localization; sphingolipid biosynthetic process; sphingosine biosynthetic process
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Reference #:
Q969W0
(UniProtKB)
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Alt. Names/Synonyms: C14orf147; MGC24447; Q969W0; Serine palmitoyltransferase small subunit A; Small subunit of serine palmitoyltransferase A; SPTSA; SPTSSA; SSSPTA
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Gene Symbols: SPTSSA
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Molecular weight:
8,466 Da
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Basal Isoelectric point:
6.7
Predict pI for various phosphorylation states
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