SPTSSA Stimulates the activity of serine palmitoyltransferase (SPT). The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. Plays a role in MBOAT7 location to mitochondria-associated membranes (MAMs), may me involved in fatty acid remodeling phosphatidylinositol (PI). Belongs to the SPTSS family. SPTSSA subfamily. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of human Ortholog: 14q13.1
Cellular Component:  endoplasmic reticulum; endoplasmic reticulum membrane; serine C-palmitoyltransferase complex
Molecular Function:  protein binding; serine C-palmitoyltransferase activity
Biological Process:  ceramide biosynthetic process; protein localization; sphingolipid biosynthetic process; sphingosine biosynthetic process
Reference #:  Q969W0 (UniProtKB)
Alt. Names/Synonyms: C14orf147; MGC24447; Q969W0; Serine palmitoyltransferase small subunit A; Small subunit of serine palmitoyltransferase A; SPTSA; SPTSSA; SSSPTA
Gene Symbols: SPTSSA
Molecular weight: 8,466 Da
Basal Isoelectric point: 6.7  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein