|
NOP10
Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine (psi) residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme. Belongs to the NOP10 family. Note: This description may include information from UniProtKB.
|
| Protein type: Nucleolus |
| Chromosomal Location of human Ortholog: 15q14 |
|
Cellular Component:
box H/ACA scaRNP complex; box H/ACA snoRNP complex; box H/ACA telomerase RNP complex; nuclear body; nucleoplasm; sno(s)RNA-containing ribonucleoprotein complex; telomerase holoenzyme complex
|
|
Molecular Function:
box H/ACA snoRNA binding; protein binding; RNA binding; telomerase RNA binding
|
|
Biological Process:
pseudouridine synthesis; rRNA pseudouridine synthesis; snRNA pseudouridine synthesis; telomere maintenance via telomerase
|
|
Disease: Cataracts, Hearing Impairment, Nephrotic Syndrome, And Enterocolitis 2; Dyskeratosis Congenita, Autosomal Recessive, 1; Pulmonary Fibrosis And/or Bone Marrow Failure Syndrome, Telomere-related, 9
|
|
Reference #:
Q9NPE3
(UniProtKB)
|
|
Alt. Names/Synonyms: DKCB1; H/ACA ribonucleoprotein complex subunit 3; homolog of yeast Nop10p; MGC70651; NOLA3; NOP10; NOP10 ribonucleoprotein; NOP10 ribonucleoprotein homolog; NOP10 ribonucleoprotein homolog (yeast); NOP10P; Nucleolar protein 10; Nucleolar protein family A member 3; nucleolar protein family A, member 3; nucleolar protein family A, member 3 (H/ACA small nucleolar RNPs); Q9NPE3; snoRNP protein NOP10
|
|
Gene Symbols: NOP10
|
|
Molecular weight:
7,706 Da
|
|
Basal Isoelectric point:
10.01
Predict pI for various phosphorylation states
|
