NKG7
Belongs to the PMP-22/EMP/MP20 family. Expressed in activated T-cells, in kidney, liver, lung and pancreas. Not expressed in brain, heart, or skeletal muscle. Expressed at high levels in TCR gamma delta-expressing CTL clones, and in some TCR alpha beta-expressing CTL clones (both CD4+ and CD8+), but is not expressed in other TCR alpha beta-expressing CTL clones and in cell lines representing B-cells, monocytes, and myeloid cells. Note: This description may include information from UniProtKB.
|
Protein type: Membrane protein, integral; Membrane protein, multi-pass |
Chromosomal Location of human Ortholog: 19q13.41 |
Cellular Component:
cytolytic granule; cytolytic granule membrane; plasma membrane
|
Molecular Function:
protein binding
|
Biological Process:
CD4-positive, alpha-beta T cell activation; defense response to protozoan; granzyme-mediated programmed cell death signaling pathway; inflammatory response; killing of cells of another organism; natural killer cell degranulation; natural killer cell mediated cytotoxicity; natural killer cell mediated cytotoxicity directed against tumor cell target; positive regulation of inflammatory response
|
Reference #:
Q16617
(UniProtKB)
|
Alt. Names/Synonyms: G-CSF-induced gene 1 protein; GIG-1 protein; GIG1; GMP-17; granule membrane protein 17; Granule membrane protein of 17 kDa; natural killer cell granule protein 7; natural killer cell group 7 sequence; Natural killer cell protein 7; NKG7; p15-TIA-1; Protein NKG7; Q16617
|
Gene Symbols: NKG7
|
Molecular weight:
17,665 Da
|
Basal Isoelectric point:
5.88
Predict pI for various phosphorylation states
|
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
|