LDLRAD3 May influence APP processing, resulting in a decrease in sAPP-alpha production and increased amyloidogenic P3 peptide production. Belongs to the LDLR family. Expressed at high levels in brain, lung, skeletal muscle, and pancreas. Expressed at moderate levels in heart, placenta, and kidney but not detected in the liver. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 11p13
Cellular Component:  integral component of membrane; plasma membrane
Molecular Function:  amyloid-beta binding
Biological Process:  receptor-mediated endocytosis; regulation of protein processing
Reference #:  Q86YD5 (UniProtKB)
Alt. Names/Synonyms: LDLR class A domain-containing protein 3; LDLRAD3; low density lipoprotein receptor class A domain containing 3; Low-density lipoprotein receptor class A domain-containing protein 3; LRAD3; Q86YD5
Gene Symbols: LDLRAD3
Molecular weight: 37,419 Da
Basal Isoelectric point: 4.74  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein