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NFKBID
Regulates the expression of IL-2, IL-6, and other cytokines through regulation on NF-kappa-B activity. Functions in the regulation of inflammatory responses. Involved in the induction of T helper 17 cells (Th17) differentiation upon recognition of antigen by T cell antigen receptor (TCR). May also regulate TCR-induced negative selection of thymocytes. Belongs to the NF-kappa-B inhibitor family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Chromosomal Location of human Ortholog: 19q13.12 |
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Cellular Component:
nucleus
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Molecular Function:
protein binding
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Biological Process:
inflammatory response; positive regulation of T-helper 17 cell differentiation; regulation of gene expression; T cell receptor signaling pathway
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Reference #:
Q8NI38
(UniProtKB)
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Alt. Names/Synonyms: I-kappa-B-delta; IkappaBdelta; IkappaBNS; IkB-delta; IKBD; IKBNS; MGC11314; MGC149503; NF-kappa-B inhibitor delta; NFKB inhibitor delta; NFKBID; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta; Q8NI38; T-cell activation NFKB-like protein; TA-NFKBH
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Gene Symbols: NFKBID
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Molecular weight:
33,481 Da
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Basal Isoelectric point:
6.9
Predict pI for various phosphorylation states
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