RLN2 Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix. Belongs to the insulin family. Isoform 1 is expressed in the ovary during pregnancy. Also expressed in placenta, decidua and prostate. Isoform 2 is relatively abundant in placenta. It is in much lower abundance in the prostate gland. Not detected in the ovary. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of human Ortholog: 9p24.1
Cellular Component:  extracellular region
Molecular Function:  hormone activity
Biological Process:  female pregnancy; positive regulation of angiogenesis; positive regulation of gene expression; regulation of catalytic activity; signal transduction
Reference #:  P04090 (UniProtKB)
Alt. Names/Synonyms: bA12D24.1.1; bA12D24.1.2; H2; H2-preprorelaxin; H2-RLX; Prorelaxin H2; REL2; relaxin 2; Relaxin A chain; Relaxin B chain; relaxin H2; relaxin, ovarian, of pregnancy; RLN2; RLXH2
Gene Symbols: RLN2
Molecular weight: 21,043 Da
Basal Isoelectric point: 8.88  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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