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RLN2
Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix. Belongs to the insulin family. Isoform 1 is expressed in the ovary during pregnancy. Also expressed in placenta, decidua and prostate. Isoform 2 is relatively abundant in placenta. It is in much lower abundance in the prostate gland. Not detected in the ovary. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Secreted; Secreted, signal peptide |
| Chromosomal Location of human Ortholog: 9p24.1 |
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Cellular Component:
extracellular region
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Molecular Function:
hormone activity
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Biological Process:
female pregnancy; positive regulation of angiogenesis; positive regulation of gene expression; regulation of catalytic activity; signal transduction
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Reference #:
P04090
(UniProtKB)
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Alt. Names/Synonyms: bA12D24.1.1; bA12D24.1.2; H2; H2-preprorelaxin; H2-RLX; Prorelaxin H2; REL2; relaxin 2; Relaxin A chain; Relaxin B chain; relaxin H2; relaxin, ovarian, of pregnancy; RLN2; RLXH2
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Gene Symbols: RLN2
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Molecular weight:
21,043 Da
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Basal Isoelectric point:
8.88
Predict pI for various phosphorylation states
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