EphA1 Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC. Plays also a role in angiogenesis and regulates cell proliferation. May play a role in apoptosis. Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. Overexpressed in several carcinomas. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Eph family; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group
Chromosomal Location of mouse Ortholog: 6|6 B2.1
Cellular Component:  membrane; plasma membrane; receptor complex
Molecular Function:  ATP binding; ephrin receptor activity; fibronectin binding; kinase activity; nucleotide binding; protein binding; protein kinase activity; protein kinase binding; protein tyrosine kinase activity; transferase activity; transmembrane receptor protein tyrosine kinase activity; transmembrane-ephrin receptor activity
Biological Process:  activation of GTPase activity; angiogenesis; cell adhesion; cell surface receptor signaling pathway; ephrin receptor signaling pathway; multicellular organism development; negative regulation of cell migration; negative regulation of protein kinase activity; peptidyl-tyrosine phosphorylation; phosphorylation; positive regulation of angiogenesis; positive regulation of cell migration; positive regulation of cell population proliferation; positive regulation of cell-matrix adhesion; positive regulation of kinase activity; positive regulation of stress fiber assembly; protein autophosphorylation; protein phosphorylation; regulation of GTPase activity; substrate adhesion-dependent cell spreading; transmembrane receptor protein tyrosine kinase signaling pathway
Reference #:  Q60750 (UniProtKB)
Alt. Names/Synonyms: 5730453L17Rik; AL033318; Embryonic stem cell kinase; Eph; Eph receptor A1; Epha1; Ephrin type-A receptor 1; Esk; mEpha1; Tyrosine-protein kinase receptor ESK
Gene Symbols: Epha1
Molecular weight: 108,578 Da
Basal Isoelectric point: 5.92  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein