DDR2 Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing. Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. Detected in osteocytes, osteoblastic cells in subchondral bone, bone lining cells, tibia and cartilage (at protein level). Detected at high levels in heart and lung, and at low levels in brain, placenta, liver, skeletal muscle, pancreas, and kidney. Note: This description may include information from UniProtKB.
Protein type: DDR family; EC 2.7.10.1; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group
Chromosomal Location of mouse Ortholog: 1 H3|1 76.84 cM
Cellular Component:  actin cytoskeleton; apical plasma membrane; integral component of membrane; integral component of plasma membrane; membrane; plasma membrane; receptor complex
Molecular Function:  ATP binding; collagen binding; kinase activity; nucleotide binding; protein kinase activity; protein tyrosine kinase activity; protein tyrosine kinase collagen receptor activity; transferase activity; transmembrane receptor protein tyrosine kinase activity
Biological Process:  biomineral tissue development; cell differentiation; cell-matrix adhesion; chondrocyte proliferation; collagen fibril organization; collagen-activated tyrosine kinase receptor signaling pathway; endochondral bone growth; ossification; peptidyl-tyrosine phosphorylation; phosphorylation; positive regulation of cell proliferation; positive regulation of DNA-binding transcription factor activity; positive regulation of extracellular matrix disassembly; positive regulation of fibroblast migration; positive regulation of fibroblast proliferation; positive regulation of osteoblast differentiation; positive regulation of protein kinase activity; protein autophosphorylation; protein phosphorylation; regulation of bone mineralization; regulation of cell-matrix adhesion; regulation of extracellular matrix organization; transmembrane receptor protein tyrosine kinase signaling pathway
Reference #:  Q62371 (UniProtKB)
Alt. Names/Synonyms: AW495251; CD167 antigen-like family member B; CD167b; Ddr2; Discoidin domain receptor 2; discoidin domain receptor family, member 2; Discoidin domain-containing receptor 2; Neurotrophic tyrosine kinase, receptor-related 3; Ntr; Ntrkr3; Receptor protein-tyrosine kinase TKT; Tkt; Tyro10; Tyrosine-protein kinase TYRO10
Gene Symbols: Ddr2
Molecular weight: 96,482 Da
Basal Isoelectric point: 5.31  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
Select Structure to View Below

DDR2

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene