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DDR2
Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing. Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. Detected in osteocytes, osteoblastic cells in subchondral bone, bone lining cells, tibia and cartilage (at protein level). Detected at high levels in heart and lung, and at low levels in brain, placenta, liver, skeletal muscle, pancreas, and kidney. Note: This description may include information from UniProtKB.
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| Protein type: DDR family; EC 2.7.10.1; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group |
| Chromosomal Location of human Ortholog: 1q23.3 |
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Cellular Component:
actin cytoskeleton; apical plasma membrane; plasma membrane; receptor complex
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Molecular Function:
ATP binding; collagen binding; protein binding; protein tyrosine kinase collagen receptor activity; transmembrane receptor protein tyrosine kinase activity
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Biological Process:
biomineral tissue development; cell adhesion; cellular response to angiotensin; cellular response to hypoxia; cellular response to transforming growth factor beta stimulus; chondrocyte proliferation; collagen fibril organization; collagen-activated tyrosine kinase receptor signaling pathway; endochondral bone growth; multicellular organism development; negative regulation of apoptotic process; negative regulation of hydrogen peroxide-mediated programmed cell death; negative regulation of kinase activity; ossification; peptidyl-tyrosine phosphorylation; positive regulation of collagen biosynthetic process; positive regulation of DNA-binding transcription factor activity; positive regulation of ERK1 and ERK2 cascade; positive regulation of extracellular matrix disassembly; positive regulation of fibroblast migration; positive regulation of fibroblast proliferation; positive regulation of G1/S transition of mitotic cell cycle; positive regulation of hepatic stellate cell activation; positive regulation of hepatic stellate cell proliferation; positive regulation of kinase activity; positive regulation of neuron death; positive regulation of neuron projection development; positive regulation of osteoblast differentiation; positive regulation of phosphatidylinositol 3-kinase signaling; positive regulation of protein kinase activity; positive regulation of vascular associated smooth muscle cell migration; positive regulation of vascular associated smooth muscle cell proliferation; positive regulation of wound healing; protein autophosphorylation; regulation of bone mineralization; regulation of extracellular matrix disassembly; regulation of tissue remodeling; response to muscle stretch; signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway
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Disease: Spondylometaepiphyseal Dysplasia, Short Limb-hand Type; Warburg-cinotti Syndrome
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Reference #:
Q16832
(UniProtKB)
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Alt. Names/Synonyms: CD167 antigen-like family member B; CD167b; cell migration-inducing protein 20; DDR2; Discoidin domain receptor 2; discoidin domain receptor family, member 2; discoidin domain receptor tyrosine kinase 2; Discoidin domain-containing receptor 2; Discoidin domain-containing receptor tyrosine kinase 2; hydroxyaryl-protein kinase; MIG20a; migration-inducing gene 16 protein; neurotrophic tyrosine kinase receptor related 3; Neurotrophic tyrosine kinase, receptor-related 3; NTRKR3; Receptor protein-tyrosine kinase TKT; TKT; TYRO10; Tyrosine-protein kinase TYRO10; WRCN
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Gene Symbols: DDR2
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Molecular weight:
96,736 Da
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Basal Isoelectric point:
5.2
Predict pI for various phosphorylation states
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CST Pathways:
Tyrosine Kinases & Substrates
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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