DDR1
Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing. Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Also plays a role in tumor cell invasion. Phosphorylates PTPN11. Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. Detected in T-47D, MDA-MB-175 and HBL-100 breast carcinoma cells, A-431 epidermoid carcinoma cells, SW48 and SNU-C2B colon carcinoma cells and Hs 294T melanoma cells (at protein level). Expressed at low levels in most adult tissues and is highest in the brain, lung, placenta and kidney. Lower levels of expression are detected in melanocytes, heart, liver, skeletal muscle and pancreas. Abundant in breast carcinoma cell lines. In the colonic mucosa, expressed in epithelia but not in the connective tissue of the lamina propria. In the thyroid gland, expressed in the epithelium of the thyroid follicles. In pancreas, expressed in the islets of Langerhans cells, but not in the surrounding epithelial cells of the exocrine pancreas. In kidney, expressed in the epithelia of the distal tubules. Not expressed in connective tissue, endothelial cells, adipose tissue, muscle cells or cells of hematopoietic origin. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DDR family; EC 2.7.10.1; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group
Molecular Function: ATP binding; collagen binding; metal ion binding; protein tyrosine kinase collagen receptor activity; transmembrane receptor protein tyrosine kinase activity
Biological Process: animal organ regeneration; axon development; branching involved in mammary gland duct morphogenesis; cell population proliferation; collagen-activated tyrosine kinase receptor signaling pathway; ear development; embryo implantation; lactation; mammary gland alveolus development; multicellular organism development; negative regulation of cell population proliferation; neuron projection extension; peptidyl-tyrosine autophosphorylation; peptidyl-tyrosine phosphorylation; positive regulation of ERK1 and ERK2 cascade; positive regulation of kinase activity; positive regulation of neuron projection development; positive regulation of phosphatidylinositol 3-kinase signaling; protein autophosphorylation; protein phosphorylation; regulation of cell growth; regulation of cell-matrix adhesion; regulation of extracellular matrix disassembly; skin development; smooth muscle cell migration; smooth muscle cell-matrix adhesion; transmembrane receptor protein tyrosine kinase signaling pathway; wound healing, spreading of cells
