CTK Could play a significant role in the signal transduction of hematopoietic cells. May regulate tyrosine kinase activity of SRC-family members in brain by specifically phosphorylating their C-terminal regulatory tyrosine residue which acts as a negative regulatory site. It may play an inhibitory role in the control of T-cell proliferation. Belongs to the protein kinase superfamily. Tyr protein kinase family. CSK subfamily. Expressed in various myeloid cell lines, detected in brain and lung. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Csk family; EC 2.7.10.2; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); TK group
Chromosomal Location of Human Ortholog: 10 39.72 cM|10 C1
Cellular Component:  cytoplasm; extrinsic component of cytoplasmic side of plasma membrane; membrane
Molecular Function:  ATP binding; kinase activity; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein kinase activity; protein tyrosine kinase activity; transferase activity
Biological Process:  phosphorylation; protein phosphorylation; regulation of cell proliferation
Reference #:  P41242 (UniProtKB)
Alt. Names/Synonyms: CHK; Csk homologous kinase; Ctk; HYL; Matk; megakaryocyte-associated tyrosine kinase; Megakaryocyte-associated tyrosine-protein kinase; MGC130505; Ntk; p56ntk; Protein kinase NTK; tyrosine protein kinase; Tyrosine-protein kinase CTK
Gene Symbols: Matk
Molecular weight: 56,056 Da
Basal Isoelectric point: 9.01  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
Select Structure to View Below

CTK

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene