FZD1
Receptor for Wnt proteins. Activated by WNT3A, WNT3, WNT1 and to a lesser extent WNT2, but apparently not by WNT4, WNT5A, WNT5B, WNT6, WNT7A or WNT7B. Contradictory results showing activation by WNT7B have been described for mouse. Functions in the canonical Wnt/beta-catenin signaling pathway. The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Belongs to the G-protein coupled receptor Fz/Smo family. Expressed in adult heart, placenta, lung, kidney, pancreas, prostate, and ovary and in fetal lung and kidney. Note: This description may include information from UniProtKB.
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Protein type: GPCR, Fz/Smo family; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR |
Chromosomal Location of human Ortholog: 7q21.13 |
Cellular Component:
cell surface; plasma membrane; Wnt signalosome
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Molecular Function:
frizzled binding; G protein-coupled receptor activity; PDZ domain binding; protein binding; signaling receptor binding; Wnt receptor activity; Wnt-protein binding
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Biological Process:
astrocyte-dopaminergic neuron signaling; autocrine signaling; canonical Wnt signaling pathway; canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation; canonical Wnt signaling pathway involved in osteoblast differentiation; cell-cell signaling; endothelial cell differentiation; G protein-coupled receptor signaling pathway; hard palate development; membranous septum morphogenesis; muscular septum morphogenesis; negative regulation of BMP signaling pathway; negative regulation of canonical Wnt signaling pathway; negative regulation of DNA-templated transcription; negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway; neuron differentiation; non-canonical Wnt signaling pathway; outflow tract morphogenesis; planar cell polarity pathway involved in neural tube closure; positive regulation of DNA-binding transcription factor activity; positive regulation of DNA-templated transcription; positive regulation of neuron projection development; positive regulation of protein phosphorylation; presynapse assembly; regulation of presynapse assembly; response to xenobiotic stimulus; Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation
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Reference #:
Q9UP38
(UniProtKB)
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Alt. Names/Synonyms: DKFZp564G072; FLJ95923; frizzled 1, seven transmembrane spanning receptor; frizzled class receptor 1; frizzled family receptor 1; frizzled homolog 1; frizzled homolog 1 (Drosophila); frizzled, Drosophila, homolog of, 1; Frizzled-1; Fz-1; FZD1; FzE1; hFz1; Wnt receptor
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Gene Symbols: FZD1
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Molecular weight:
71,158 Da
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Basal Isoelectric point:
8.33
Predict pI for various phosphorylation states
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CST Pathways:
ESC Pluripotency and Differentiation
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mTOR Signaling
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Translation: eIF4E and p70S6K
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Wnt/ß-Catenin Signaling
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Select Structure to View Below |
FZD1
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