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SLC38A3
Sodium-dependent amino acid/proton antiporter. Mediates electrogenic cotransport of glutamine and sodium ions in exchange for protons. Also recognizes histidine, asparagine and alanine. May mediate amino acid transport in either direction under physiological conditions. May play a role in nitrogen metabolism and synaptic transmission. Belongs to the amino acid/polyamine transporter 2 family. Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family |
| Chromosomal Location of rat Ortholog: 8q32 |
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Cellular Component:
apical plasma membrane; basolateral plasma membrane; membrane; plasma membrane
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Molecular Function:
L-alanine transmembrane transporter activity; L-asparagine transmembrane transporter activity; L-asparagine, sodium:proton antiporter activity; L-glutamine transmembrane transporter activity; L-glutamine, sodium:proton antiporter activity; L-histidine transmembrane transporter activity; L-histidine, sodium:proton antiporter activity; neutral L-amino acid:sodium symporter activity
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Biological Process:
amino acid transmembrane transport; asparagine transport; cellular response to potassium ion starvation; female pregnancy; glutamine secretion; glutamine transport; histidine transport; inorganic cation transmembrane transport; intracellular amino acid homeostasis; L-alanine transport; L-asparagine import across plasma membrane; L-glutamine import across plasma membrane; L-histidine import across plasma membrane; L-histidine transport; monoatomic cation transmembrane transport; positive regulation of glutamine transport; positive regulation of transcription from RNA polymerase II promoter in response to acidic pH; sodium ion transport
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Reference #:
Q9JHZ9
(UniProtKB)
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Alt. Names/Synonyms: N-system amino acid transporter 1; Na(+)-coupled neutral amino acid transporter 3; S38A3; Slc38a3; Snat3; Sodium-coupled neutral amino acid transporter 3; Solute carrier family 38 member 3; System N amino acid transporter 1
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Gene Symbols: Slc38a3
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Molecular weight:
55,637 Da
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Basal Isoelectric point:
6.46
Predict pI for various phosphorylation states
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