AACS Activates acetoacetate to acetoacetyl-CoA. May be involved in utilizing ketone body for the fatty acid-synthesis during adipose tissue development. Belongs to the ATP-dependent AMP-binding enzyme family. Highly expressed in kidney, heart and brain, but low in liver. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - butanoate; EC; Ligase
Chromosomal Location of rat Ortholog: 12q14
Cellular Component:  cytosol
Molecular Function:  acetoacetate-CoA ligase activity; ATP binding; butyrate-CoA ligase activity
Biological Process:  adipose tissue development; cellular response to cholesterol; cellular response to glucose stimulus; cellular response to testosterone stimulus; fatty acid metabolic process; liver development; positive regulation of insulin secretion; response to drug; response to ethanol; response to nutrient; response to oleic acid; response to organic cyclic compound; response to organonitrogen compound; response to purine-containing compound; response to starvation; white fat cell differentiation
Reference #:  Q9JMI1 (UniProtKB)
Alt. Names/Synonyms: Aacs; Acetoacetyl-CoA synthetase; Q9JMI1
Gene Symbols: Aacs
Molecular weight: 75,040 Da
Basal Isoelectric point: 6.05  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein