SRC-3
Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit. Belongs to the SRC/p160 nuclear receptor coactivator family. Widely expressed. High expression in heart, skeletal muscle, pancreas and placenta. Low expression in brain, and very low in lung, liver and kidney. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor |
Chromosomal Location of rat Ortholog: 3q42 |
Cellular Component:
chromatin; cytoplasm; cytosol; nucleoplasm; nucleus; perinuclear region of cytoplasm; protein-containing complex; RNA polymerase II transcription regulator complex
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Molecular Function:
chromatin binding; disordered domain specific binding; DNA-binding transcription activator activity, RNA polymerase II-specific; histone acetyltransferase activity; molecular adaptor activity; nuclear androgen receptor binding; nuclear estrogen receptor binding; nuclear receptor binding; nuclear receptor coactivator activity; peroxisome proliferator activated receptor binding; protein dimerization activity; protein-containing complex binding; RNA polymerase II complex binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; transcription coactivator activity
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Biological Process:
cell dedifferentiation; cellular response to estradiol stimulus; cellular response to hormone stimulus; cerebellum development; chromatin remodeling; labyrinthine layer morphogenesis; male gonad development; mammary gland branching involved in thelarche; multicellular organism growth; negative regulation of apoptotic process; negative regulation of stem cell differentiation; positive regulation of cell growth; positive regulation of DNA-binding transcription factor activity; positive regulation of gene expression; positive regulation of intracellular estrogen receptor signaling pathway; positive regulation of intracellular steroid hormone receptor signaling pathway; positive regulation of keratinocyte differentiation; positive regulation of stem cell population maintenance; positive regulation of transcription by RNA polymerase II; regulation of stem cell division; regulation of stem cell population maintenance; regulation of stem cell proliferation
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Reference #:
Q9EPU2
(UniProtKB)
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Alt. Names/Synonyms: Aib1; Ncoa3; Nuclear receptor coactivator 3; nuclear receptor coactivator AIB1; Q9EPU2; SRC-3
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Gene Symbols: Ncoa3
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Molecular weight:
115,157 Da
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Basal Isoelectric point:
8.71
Predict pI for various phosphorylation states
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CST Pathways:
Protein Acetylation
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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