CYP19A1 Catalyzes the formation of aromatic C18 estrogens from C19 androgens. Belongs to the cytochrome P450 family. Note: This description may include information from UniProtKB.
Protein type: EC; Lipid Metabolism - androgen and estrogen; Oxidoreductase
Chromosomal Location of Human Ortholog: 15q21.2
Cellular Component:  endoplasmic reticulum; endoplasmic reticulum membrane; membrane
Molecular Function:  electron transfer activity; heme binding; iron ion binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; oxygen binding; steroid hydroxylase activity
Biological Process:  androgen catabolic process; estrogen biosynthetic process; female genitalia development; female gonad development; mammary gland development; negative regulation of chronic inflammatory response; steroid biosynthetic process; sterol metabolic process; uterus development
Disease: Aromatase Deficiency; Aromatase Excess Syndrome
Reference #:  P11511 (UniProtKB)
Alt. Names/Synonyms: ARO; ARO1; Aromatase; CP19A; CPV1; CYAR; CYP19; CYP19A1; CYPXIX; Cytochrome P-450AROM; Cytochrome P450 19A1; cytochrome P450, family 19, subfamily A, polypeptide 1; cytochrome P450, subfamily XIX (aromatization of androgens); Estrogen synthase; estrogen synthetase; flavoprotein-linked monooxygenase; MGC104309; microsomal monooxygenase; P-450AROM
Gene Symbols: CYP19A1
Molecular weight: 57,883 Da
Basal Isoelectric point: 7.2  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein