RUNX1T1 Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes. Can repress the expression of MMP7 in a ZBTB33-dependent manner. Can repress transactivation mediated by TCF12. Acts as a negative regulator of adipogenesis. The AML1-MTG8/ETO fusion protein frequently found in leukemic cells is involved in leukemogenesis and contributes to hematopoietic stem/progenitor cell self-renewal. Belongs to the CBFA2T family. Most abundantly expressed in brain. Lower levels in lung, heart, testis and ovary. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Oncoprotein; Transcription regulation
Chromosomal Location of Human Ortholog: 4 A1|4 5.88 cM
Cellular Component:  nuclear matrix; nucleoplasm; nucleus
Molecular Function:  DNA-binding transcription factor activity; metal ion binding; protein binding; protein homodimerization activity; transcription corepressor activity
Biological Process:  fat cell differentiation; negative regulation of fat cell differentiation; negative regulation of transcription, DNA-templated; regulation of DNA binding; regulation of transcription, DNA-templated
Reference #:  Q61909 (UniProtKB)
Alt. Names/Synonyms: acute myelogenous leukemia 1 translocation 1 protein; Cbfa2t1; CBFA2T1 identified gene homolog; Cbfa2t1h; ETO; Mtg8; OTTMUSP00000004832; Protein CBFA2T1; Protein MTG8; runt-related transcription factor 1; RUNX1 translocation partner 1; Runx1t1; translocated to, 1 (cyclin D-related)
Gene Symbols: Runx1t1
Molecular weight: 64,338 Da
Basal Isoelectric point: 7.13  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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RUNX1T1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene