CCK4 Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis. Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: CCK4 family; EC 2.7.10.1; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group
Chromosomal Location of Human Ortholog: 6p21.1
Cellular Component:  cell-cell junction; integral component of plasma membrane
Molecular Function:  ATP binding; coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway; protein binding; protein kinase activity
Biological Process:  actin cytoskeleton reorganization; cell adhesion; cell migration; cellular response to retinoic acid; cochlea morphogenesis; convergent extension; coronary vasculature development; establishment of epithelial cell apical/basal polarity; lung-associated mesenchyme development; planar cell polarity pathway involved in neural tube closure; positive regulation of canonical Wnt signaling pathway; positive regulation of neuron projection development; protein phosphorylation; signal transduction; ventricular septum development; wound healing
Reference #:  Q13308 (UniProtKB)
Alt. Names/Synonyms: CCK-4; CCK4; Colon carcinoma kinase 4; colon carcinoma kinase-4; Inactive tyrosine-protein kinase 7; Protein-tyrosine kinase 7; PTK7; PTK7 protein tyrosine kinase 7; Tyrosine-protein kinase-like 7
Gene Symbols: PTK7
Molecular weight: 118,392 Da
Basal Isoelectric point: 6.67  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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CCK4

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein