CCK4 Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis. Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. Highly expressed in lung, liver, pancreas, kidney, placenta and melanocytes. Weakly expressed in thyroid gland, ovary, brain, heart and skeletal muscle. Also expressed in erythroleukemia cells. But not expressed in colon. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: CCK4 family; EC 2.7.10.1; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group
Chromosomal Location of Human Ortholog: 6p21.1
Cellular Component:  cell-cell junction; integral component of plasma membrane
Molecular Function:  ATP binding; coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway; protein binding; protein kinase activity
Biological Process:  actin cytoskeleton reorganization; cell adhesion; cell migration; cellular response to retinoic acid; cochlea morphogenesis; convergent extension; coronary vasculature development; establishment of epithelial cell apical/basal polarity; lung-associated mesenchyme development; planar cell polarity pathway involved in neural tube closure; positive regulation of canonical Wnt signaling pathway; positive regulation of neuron projection development; protein phosphorylation; signal transduction; ventricular septum development; wound healing
Reference #:  Q13308 (UniProtKB)
Alt. Names/Synonyms: CCK-4; CCK4; Colon carcinoma kinase 4; colon carcinoma kinase-4; Inactive tyrosine-protein kinase 7; Protein-tyrosine kinase 7; PTK7; PTK7 protein tyrosine kinase 7; Tyrosine-protein kinase-like 7
Gene Symbols: PTK7
Molecular weight: 118,392 Da
Basal Isoelectric point: 6.67  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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CCK4

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein