Tyro3 Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3. Monomer and homodimer. Interacts (via N-terminus) with extracellular ligands TUB, TULP1 and GAS6. Interacts with PIK3R1; this interaction increases PI3-kinase activity. Abundant in the brain and lower levels in other tissues. Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily. Note: This description may include information from UniProtKB.
Protein type: Axl family; EC 2.7.10.1; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group
Chromosomal Location of Human Ortholog: 3q35
Cellular Component:  cell surface; endoplasmic reticulum membrane; integral component of membrane; integral component of plasma membrane; nuclear envelope; nucleus; receptor complex
Molecular Function:  ATP binding; phosphatidylinositol 3-kinase binding; protein heterodimerization activity; protein tyrosine kinase activity; transmembrane receptor protein tyrosine kinase activity; Wnt-protein binding
Biological Process:  apoptotic cell clearance; forebrain cell migration; natural killer cell differentiation; negative regulation of inflammatory response; negative regulation of innate immune response; negative regulation of lymphocyte activation; negative regulation of neuron apoptotic process; negative regulation of toll-like receptor signaling pathway; neuron cellular homeostasis; neuropeptide signaling pathway; ovulation cycle; peptidyl-tyrosine phosphorylation; platelet activation; platelet aggregation; protein autophosphorylation; protein kinase B signaling; protein phosphorylation; secretion by cell; spermatogenesis; substrate adhesion-dependent cell spreading; transmembrane receptor protein tyrosine kinase signaling pathway; vagina development; Wnt signaling pathway
Reference #:  P55146 (UniProtKB)
Alt. Names/Synonyms: Brt; Bruton agammaglobulinemia tyrosine kinase; Sky; Tyro3; TYRO3 protein tyrosine kinase; TYRO3 protein tyrosine kinase 3; Tyrosine-protein kinase receptor TYRO3; Tyrosine-protein kinase SKY
Gene Symbols: Tyro3
Molecular weight: 95,919 Da
Basal Isoelectric point: 5.54  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Tyro3

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene