SRSF10 iso4 Splicing factor that in its dephosphorylated form acts as a general repressor of pre-mRNA splicing. Seems to interfere with the U1 snRNP 5'-splice recognition of SNRNP70. Required for splicing repression in M-phase cells and after heat shock. Also acts as a splicing factor that specifically promotes exon skipping during alternative splicing. Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing. May be involved in regulation of alternative splicing in neurons, with isoform 1 acting as a positive and isoform 3 as a negative regulator. Belongs to the splicing factor SR family. Widely expressed. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: RNA splicing; RNA-binding
Chromosomal Location of Human Ortholog: 1p36.11
Cellular Component:  cytoplasm; cytosol; nuclear speck; nucleoplasm; nucleus
Molecular Function:  protein binding; RNA binding; RS domain binding; unfolded protein binding
Biological Process:  cytosolic transport; mRNA splice site selection; mRNA splicing, via spliceosome; negative regulation of mRNA splicing, via spliceosome; regulation of mRNA splicing, via spliceosome; regulation of transcription, DNA-templated; RNA splicing, via transesterification reactions; spliceosomal tri-snRNP complex assembly
Reference #:  O75494-4 (UniProtKB)
Alt. Names/Synonyms: 40 kDa SR-repressor protein; FUS interacting protein (serine-arginine rich) 1; FUS-interacting protein (serine-arginine rich) 2; FUS-interacting serine-arginine-rich protein 1; FUSIP1; FUSIP2; neural-salient SR protein; NSSR; PPP1R149; protein phosphatase 1, regulatory subunit 149; serine and arginine rich splicing factor 10; serine-arginine repressor protein (40 kDa); Serine/arginine-rich splicing factor 10; SFRS13; SFRS13A; Splicing factor SRp38; splicing factor, arginine/serine-rich 13; Splicing factor, arginine/serine-rich 13A; SR splicing factor 10; SRp38; SRrp40; SRS10; SRSF10; SRSF10 iso4; TASR; TASR1; TASR2; TLS-associated protein TASR; TLS-associated protein with Ser-Arg repeats; TLS-associated protein with SR repeats; TLS-associated serine-arginine protein; TLS-associated serine-arginine protein 1; TLS-associated serine-arginine protein 2; TLS-associated SR protein
Gene Symbols: SRSF10
Molecular weight: 21,000 Da
Basal Isoelectric point: 10.48  Predict pI for various phosphorylation states
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SRSF10 iso4

Protein Structure Not Found.

Cross-references to other databases:  cBioPortal  |  Wikipedia  |  Pfam  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein