Mer Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3. Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily. Not expressed in normal B- and T-lymphocytes but is expressed in numerous neoplastic B- and T-cell lines. Highly expressed in testis, ovary, prostate, lung, and kidney, with lower expression in spleen, small intestine, colon, and liver. Note: This description may include information from UniProtKB.

Protein type: Axl family; EC 2.7.10.1; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group

Chromosomal Location of human Ortholog: 2q13

Cellular Component: cytoplasm; extracellular space; photoreceptor outer segment; plasma membrane; receptor complex

Molecular Function: ATP binding; protein binding; transmembrane receptor protein tyrosine kinase activity

Biological Process: cell migration; cell surface receptor signaling pathway; cell-cell signaling; establishment of localization in cell; multicellular organism development; natural killer cell differentiation; negative regulation of cytokine production; negative regulation of leukocyte apoptotic process; negative regulation of lymphocyte activation; nervous system development; neutrophil clearance; phagocytosis; platelet activation; positive regulation of kinase activity; positive regulation of phagocytosis; protein kinase B signaling; protein phosphorylation; retina development in camera-type eye; secretion by cell; spermatogenesis; substrate adhesion-dependent cell spreading; transmembrane receptor protein tyrosine kinase signaling pathway; vagina development

Disease: Retinitis Pigmentosa 38

Reference #: Q12866 (UniProtKB)

Alt. Names/Synonyms: c-Eyk; c-mer; c-mer proto-oncogene tyrosine kinase; MER; MER proto-oncogene, tyrosine kinase; MER receptor tyrosine kinase; MERTK; MGC133349; Proto-oncogene c-Mer; Receptor tyrosine kinase MerTK; RP38; STK kinase; Tyro12; Tyrosine-protein kinase Mer

Gene Symbols: MERTK

Molecular weight: 110,249 Da

Basal Isoelectric point: 5.51 Predict pI for various phosphorylation states

CST Pathways: Hippo Signaling | Tyrosine Kinases & Substrates

Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology^®

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Mer

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