| DTYMK Catalyzes the conversion of dTMP to dTDP. Belongs to the thymidylate kinase family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB. |
| Protein type: EC 2.7.4.9; Kinase, other; Mitochondrial; Nucleotide Metabolism - pyrimidine |
| Chromosomal Location of human Ortholog: 2q37.3 |
| Cellular Component: cytoplasm; cytosol; mitochondrial matrix; mitochondrion; nucleus |
| Molecular Function: ATP binding; nucleoside diphosphate kinase activity; thymidylate kinase activity |
| Biological Process: cellular response to growth factor stimulus; dTDP biosynthetic process; dTTP biosynthetic process; dUDP biosynthetic process; myoblast differentiation; nucleoside monophosphate phosphorylation; phosphorylation; response to cadmium ion; response to estrogen; thymidine biosynthetic process |
| Disease: Neurodegeneration, Childhood-onset, With Progressive Microcephaly |
| Reference #: P23919 (UniProtKB) |
| Alt. Names/Synonyms: CDC8; deoxythymidylate kinase; deoxythymidylate kinase (thymidylate kinase); dTMP kinase; DTYMK; FLJ44192; KTHY; MGC198617; PP3731; Thymidylate kinase; TMPK; TYMK |
| Gene Symbols: DTYMK |
| Molecular weight: 23,819 Da |
| Basal Isoelectric point: 8.4 Predict pI for various phosphorylation states |
| Select Structure to View Below |
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DTYMK |
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Cross-references to other databases:
AlphaFold
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STRING
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cBioPortal
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Wikipedia
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Reactome
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neXtProt
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Protein Atlas
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BioGPS
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Pfam
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