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PLXNB1
Receptor for SEMA4D. Plays a role in GABAergic synapse development. Mediates SEMA4A- and SEMA4D-dependent inhibitory synapse development. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Belongs to the plexin family. Highly expressed in fetal kidney, and at slightly lower levels in fetal brain, lung and liver. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. |
| Chromosomal Location of human Ortholog: 3p21.31 |
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Cellular Component:
extracellular region; integral component of plasma membrane; plasma membrane; semaphorin receptor complex
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Molecular Function:
GTPase activating protein binding; GTPase activator activity; protein binding; semaphorin receptor activity; semaphorin receptor binding; signaling receptor activity; transmembrane signaling receptor activity
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Biological Process:
cell migration; G protein-coupled receptor signaling pathway; inhibitory synapse assembly; intracellular signal transduction; negative regulation of cell adhesion; negative regulation of osteoblast proliferation; neuron projection morphogenesis; ossification involved in bone maturation; positive regulation of GTPase activity; positive regulation of phosphatidylinositol 3-kinase signaling; regulation of cell shape; regulation of cytoskeleton organization; semaphorin-plexin signaling pathway; semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis; signal transduction
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Reference #:
O43157
(UniProtKB)
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Alt. Names/Synonyms: KIAA0407; MGC149167; plexin 5; plexin B1; Plexin-B1; PLXB1; PLXN5; PLXNB1; Semaphorin receptor SEP; SEP
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Gene Symbols: PLXNB1
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Molecular weight:
232,298 Da
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Basal Isoelectric point:
5.29
Predict pI for various phosphorylation states
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