LTK Receptor with a tyrosine-protein kinase activity. The exact function of this protein is not known. Studies with chimeric proteins (replacing its extracellular region with that of several known growth factor receptors, such as EGFR and CSFIR) demonstrate its ability to promote growth and specifically neurite outgrowth, and cell survival. Signaling appears to involve the PI3 kinase pathway. Involved in regulation of the secretory pathway involving endoplasmic reticulum (ER) export sites (ERESs) and ER to Golgi transport. Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. Expressed in non-hematopoietic cell lines and T- and B-cell lines. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Alk family; EC; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group
Chromosomal Location of human Ortholog: 15q15.1
Cellular Component:  membrane; plasma membrane
Molecular Function:  ATP binding; protein binding; protein kinase activity; protein tyrosine kinase activity
Biological Process:  cell proliferation; cellular response to retinoic acid; negative regulation of apoptotic process; peptidyl-tyrosine phosphorylation; phosphatidylinositol 3-kinase signaling; positive regulation of cardiac muscle cell apoptotic process; positive regulation of neuron projection development; protein phosphorylation; signal transduction
Reference #:  P29376 (UniProtKB)
Alt. Names/Synonyms: leukocyte receptor tyrosine kinase; leukocyte tyrosine kinase; Leukocyte tyrosine kinase receptor; LTK; Protein tyrosine kinase 1; TYK1
Gene Symbols: LTK
Molecular weight: 91,681 Da
Basal Isoelectric point: 6.07  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein