TNK1 Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction. Belongs to the protein kinase superfamily. Tyr protein kinase family. Expressed in all umbilical cord blood, bone marrow and adult blood cell sub-populations and in several leukemia cell lines. Highly expressed in fetal blood, brain, lung, liver and kidney. Detected at lower levels in adult prostate, testis, ovary, small intestine and colon. Not expressed in adult lung, liver, kidney or brain. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Ack family; EC 2.7.10.2; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); TK group
Chromosomal Location of human Ortholog: 17p13.1
Cellular Component:  cytoplasm; cytosol; membrane
Molecular Function:  ATP binding; non-membrane spanning protein tyrosine kinase activity; protein binding; protein tyrosine kinase activity
Biological Process:  negative regulation of cell growth; negative regulation of Ras protein signal transduction; protein autophosphorylation; protein phosphorylation
Reference #:  Q13470 (UniProtKB)
Alt. Names/Synonyms: CD38 negative kinase 1; KOS1; MGC46193; Non-receptor tyrosine-protein kinase TNK1; TNK1; tyrosine kinase non receptor 1; tyrosine kinase, non-receptor, 1
Gene Symbols: TNK1
Molecular weight: 72,468 Da
Basal Isoelectric point: 9.57  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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TNK1

Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene