|
GLI1 iso2
Acts as a transcriptional activator. Binds to the DNA consensus sequence 5'-GACCACCCA-3'. Regulates the transcription of specific genes during normal development. Plays a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling. Plays a role in cell proliferation and differentiation via its role in SHH signaling. Isoform 2: Acts as a transcriptional activator, but activates a different set of genes than isoform 1. Activates expression of CD24, unlike isoform 1. Mediates SHH signaling. Promotes cancer cell migration. Belongs to the GLI C2H2-type zinc-finger protein family. Detected in testis (at protein level) (PubMed:2105456). Testis, myometrium and fallopian tube. Also expressed in the brain with highest expression in the cerebellum, optic nerve and olfactory tract (PubMed:19878745). Isoform 1 is detected in brain, spleen, pancreas, liver, kidney and placenta; isoform 2 is not detectable in these tissues (PubMed:19706761). 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: C2H2-type zinc finger protein; Oncoprotein; Transcription factor |
| Chromosomal Location of human Ortholog: 12q13.3 |
|
Cellular Component:
axoneme; ciliary base; ciliary tip; cytoplasm; cytosol; GLI-SUFU complex; nucleoplasm; nucleus
|
|
Molecular Function:
chromatin binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific; metal ion binding; microtubule binding; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; transcription cis-regulatory region binding
|
|
Biological Process:
cerebellar cortex morphogenesis; digestive tract morphogenesis; dorsal/ventral pattern formation; epidermal cell differentiation; liver regeneration; lung development; negative regulation of canonical Wnt signaling pathway; notochord regression; osteoblast differentiation; pituitary gland development; positive regulation of cardiac muscle cell proliferation; positive regulation of cell cycle G1/S phase transition; positive regulation of cell population proliferation; positive regulation of DNA replication; positive regulation of DNA-templated transcription; positive regulation of smoothened signaling pathway; positive regulation of transcription by RNA polymerase II; prostate gland development; proximal/distal pattern formation; regulation of DNA-templated transcription; regulation of hepatocyte proliferation; regulation of osteoblast differentiation; regulation of smoothened signaling pathway; regulation of transcription by RNA polymerase II; response to wounding; smoothened signaling pathway; spermatid development; ventral midline development
|
|
Reference #:
P08151-2
(UniProtKB)
|
|
Alt. Names/Synonyms: GLI; GLI1; Glioma-associated oncogene; glioma-associated oncogene family zinc finger 1; Oncogene GLI; tGLI1; Zinc finger protein GLI1
|
|
Gene Symbols: GLI1
|
|
Molecular weight:
113,676 Da
|
|
Basal Isoelectric point:
6.96
Predict pI for various phosphorylation states
|
|
CST Pathways:
Hedgehog Signaling
|
